TRANSLATIONAL PHYSIOLOGY Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion
نویسندگان
چکیده
Michael Christopher, Christian Rantzau, Zhi-Ping Chen, Rodney Snow, Bruce Kemp, and Frank P. Alford Departments of Endocrinology and Diabetes and Medicine, St. Vincent’s Hospital, Fitzroy; Departments of Endocrinology and Diabetes and Medicine, University of Melbourne, Parkville; St. Vincent’s Institute of Medical Research, St. Vincent’s Hospital, Fitzroy; and School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
منابع مشابه
Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.
AMPK plays a central role in influencing fuel usage and selection. The aim of this study was to analyze the impact of low-dose AMP analog 5-aminoimidazole-4-carboxamide-1-beta-d-ribosyl monophosphate (ZMP) on whole body glucose turnover and skeletal muscle (SkM) glucose metabolism. Dogs were restudied after prior 48-h fatty acid oxidation (FA(OX)) blockade by methylpalmoxirate (MP; 5 x 12 hourl...
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The increased energy required for acute moderate exercise by skeletal muscle (SkM) is derived equally from enhanced fatty acid (FA) oxidation and glucose oxidation. Availability of FA also influences contracting SkM metabolic responses. Whole body glucose turnover and SkM glucose metabolic responses were determined in paired dog studies during 1) a 30-min moderate exercise (maximal oxygen consu...
متن کاملRegulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR.
Previous studies have shown that 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a cell-permeable activator of AMP-activated protein kinase, increases the rate of fatty acid oxidation in skeletal muscle of fed rats. The present study investigated the mechanism by which this occurs and, in particular, whether changes in the activity of malonyl-CoA decarboxylase (MCD) and the beta-isoform ...
متن کاملAMPK activation is not critical in the regulation of muscle FA uptake and oxidation during low-intensity muscle contraction.
To determine the role of AMP-activated protein kinase (AMPK) activation on the regulation of fatty acid (FA) uptake and oxidation, we perfused rat hindquarters with 6 mM glucose, 10 microU/ml insulin, 550 microM palmitate, and [14C]palmitate during rest (R) or electrical stimulation (ES), inducing low-intensity (0.1 Hz) muscle contraction either with or without 2 mM 5-aminoimidazole-4-carboxami...
متن کاملAcute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro.
To determine whether IL-6 increases lipolysis and fat oxidation in patients with type 2 diabetes and/or whether it exerts this effect independently of changes to the hormonal milieu, patients with type 2 diabetes (D) and healthy control subjects (CON) underwent recombinant human (rh)IL-6 infusion for 3 h. Rates of appearance (Ra) and disappearance (Rd) of [U-(13C)]palmitate and [6,6-(2H2)]gluco...
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تاریخ انتشار 2006